Role of Pregabalin in Treatment of Post-Op Pain in Fracture Patients

Phase 0 Completed 86 enrolled University of Alabama at Birmingham Pfizer · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

This is a randomized, prospective, double-blind pilot study designed to evaluate the potential effectiveness of pregabalin in post-operative pain management for patients who have sustained a fracture.

Timeline

Start: 2007-05
Primary completion: 2009-08
Completion: 2009-08

Publications

Background Turan A, White PF, Karamanlioglu B, Memis D, Tasdogan M, Pamukcu Z, Yavuz E. Gabapentin: an alternative to the cyclooxygenase-2 inhibitors for perioperative pain management. Anesth Analg. 2006 Jan;102(1):175-81. doi: 10.1213/01.ane.0000184824.43411.63.
Background Fischer HB, Simanski CJ. A procedure-specific systematic review and consensus recommendations for analgesia after total hip replacement. Anaesthesia. 2005 Dec;60(12):1189-202. doi: 10.1111/j.1365-2044.2005.04382.x.
Background Sills GJ. The mechanisms of action of gabapentin and pregabalin. Curr Opin Pharmacol. 2006 Feb;6(1):108-13. doi: 10.1016/j.coph.2005.11.003. Epub 2005 Dec 22.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pregabalin	Small molecule	75 mg	Oral
Subject	Pregabalin	Small molecule	150 mg	Oral

Indications

No indication recorded.