The Role of Montelukast in Rhinitis and Sleep

Summary

The hypothesis is that a leukotriene receptor antagonist (LRA), montelukast, will decrease nasal congestion leading to increased patency of the nose and a decrease in nighttime sleep fragmentation in individuals with year round allergic rhinitis or perennial allergic rhinitis (PAR). This decrease in sleep fragmentation will reduce daytime somnolence and fatigue.

Timeline

Start

2003-05

Primary completion

2009-01

Completion

2009-01

Publications

• Results Santos CB, Hanks C, McCann J, Lehman EB, Pratt E, Craig TJ. The role of montelukast on perennial allergic rhinitis and associated sleep disturbances and daytime somnolence. Allergy Asthma Proc. 2008 Mar-Apr;29(2):140-5. doi: 10.2500/aap.2008.29.3097.

Drugs

Indications