A Phase 2 Study With Panzem in Patients With Relapsed or Plateau Phase Multiple Myeloma

Phase 2 Completed 60 enrolled CASI pharmaceuticals, Inc.

Non-randomizedSingle-groupOpen-labelTreatment

Summary

The purpose of the study is to determine the safety and effectiveness of providing 2-methoxyestradiol to patients with plateau phase or relapsed multiple myeloma. Information regarding trough 2ME2 levels will also be collected.

Timeline

Start: 2001-03
Primary completion: 2008-09
Completion: 2008-09

Publications

Results Rajkumar SV, Richardson PG, Lacy MQ, Dispenzieri A, Greipp PR, Witzig TE, Schlossman R, Sidor CF, Anderson KC, Gertz MA. Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma. Clin Cancer Res. 2007 Oct 15;13(20):6162-7. doi: 10.1158/1078-0432.CCR-07-0807.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	2-methoxyestradiol	Small molecule	800 mg	Oral
Subject	2-methoxyestradiol	Small molecule	1000 mg	Oral

A Phase 2 Study With Panzem in Patients With Relapsed or Plateau Phase Multiple Myeloma

Summary

Timeline

Publications

Drugs

Indications