drugset / Trial / NCT00593879

Flexible Dose Titration Add-on Study to Treat Major Depressive Disorder

NCT00593879

Phase 2 Completed 450 enrolled Targacept Inc.
RandomizedParallel-groupQuadruple-blindTreatment

Summary

Depressed patients will receive 6 weeks of citaloprma (20-40mg) therapy. Subjects who have an inadequate response (partial or non-responder) will be randomized to receive either mecamylamine (5-10mg) or placebo added to their citalopram for a further 8 weeks.

Timeline

Start
2005-02
Primary completion
Completion
2006-08

Drugs

EvaluationDrugModalityDoseRoute
Subject Mecamylamine Small molecule 5 mg
Subject Mecamylamine Small molecule 7.5 mg
Subject Mecamylamine Small molecule 10 mg