Placebo-Controlled Crossover Study for the Investigation of the Effect of Pantoprazole on Cardiac Contractility

Phase 1 Completed 20 enrolled Herzzentrum Goettingen Gastroenterology and Endocrinology, University Medicine of Goettingen · collab Medical Statistics, University Medicine of Goettingen · collab University of Göttingen · collab

RandomizedCrossoverQuadruple-blindBasic science

Summary

Recently, negative inotropy of pantoprazole has been shown in isolated human myocardium. This study was designed to test the clinical relevance of this finding in healthy volunteers by measuring left ventricular function during infusion of a common intravenous high dose regimen of pantoprazole.

Timeline

Start: 2005-05
Primary completion: 2006-01
Completion: 2006-11

Publications

Results Schillinger W, Hornes N, Teucher N, Sossalla S, Sehrt D, Jung K, Hunlich M, Unsold B, Geiling B, Ramadori G, Hilgers R, Schworer H, Hasenfuss G. Recent in vitro findings of negative inotropy of pantoprazole did not translate into clinically relevant effects on left ventricular function in healthy volunteers. Clin Res Cardiol. 2009 Jun;98(6):391-9. doi: 10.1007/s00392-009-0012-6. Epub 2009 Mar 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Pantoprazole	Other / unclassified	8 mg	Intravenous

Indications

No indication recorded.