Comparison of Two Pharmacological Treatments of Pedophilia

Phase 3 Terminated 48 enrolled French National Institute of Health and Medical Research Assistance Publique - Hôpitaux de Paris · collab Ministry of Health, France · collab Ministry of Higher Education and Research, France · collab

RandomizedParallel-groupQuadruple-blindTreatment

Summary

Sexual abuse committed on children is a major public health problem because of its frequency and its severe consequences on the mental health of victims. Objective: to compare the therapeutic efficacy of cyproterone acetate (CPA) and leuprolide, with the hypothesis that leuprolide will be more effective.

Timeline

Start: 2007-12
Primary completion: 2009-06
Completion: 2009-06

Publications

Moulier V, Fonteille V, Pelegrini-Issac M, Cordier B, Baron-Laforet S, Boriasse E, Durand E, Stoleru S. A pilot study of the effects of gonadotropin-releasing hormone agonist therapy on brain activation pattern in a man with pedophilia. Int J Offender Ther Comp Criminol. 2012 Feb;56(1):50-60. doi: 10.1177/0306624X10392191. Epub 2011 Apr 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Leuprolide	Other / unclassified	3.75 mg	Subcutaneous
Comparator	cyproterone acetate	Small molecule	2 mg/kg	Oral

Comparison of Two Pharmacological Treatments of Pedophilia

Summary

Timeline

Publications

Drugs

Indications