drugset

drugset / Trial / NCT00602927

Effects of Varenicline on Brain Activity During Nicotine Abstinence

NCT00602927 ↗

Completed 38 enrolled University of Pennsylvania National Cancer Institute (NCI) · collab Pfizer · collab

RandomizedCrossoverTriple-blindTreatment

Summary

This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.

Timeline

Start: 2007-11
Primary completion: 2008-08
Completion: 2008-08

Publications

Results Loughead J, Ray R, Wileyto EP, Ruparel K, Sanborn P, Siegel S, Gur RC, Lerman C. Effects of the alpha4beta2 partial agonist varenicline on brain activity and working memory in abstinent smokers. Biol Psychiatry. 2010 Apr 15;67(8):715-21. doi: 10.1016/j.biopsych.2010.01.016. Epub 2010 Mar 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Varenicline	Small molecule	1 mg	—

Indications