drugset / Trial / NCT00609375
Efficacy of Cefepime Continuous Infusion Versus an Intermittent Dosing Regimen
Phase 4
Completed
30 enrolled
Javeriana University
Asociacion Colombiana de Infectologia, ACIN. Infectious Diseases Society of Colombia · collabClinica Palermo, Bogota · collabFundación San Carlos, Bogota · collabHospital Santa Clara, Bogota · collabHospital Simon Bolivar, Bogota · collabHospital san Jorge, Pereira · collabHospital san Juan de Dios, Antioquia · collab
RandomizedParallel-groupTriple-blindTreatment
Summary
To determine the efficacy of the administration of 7 to 14 days of cefepime in a continuous infusion vs an intermittent (every 8 hours) administration, in adult patients hospitalized in Bogotá with sepsis and bacteremia caused by gram negative bacilli. The outcome was the rate of clinical cure and microbiological cure after 7 and 14 days of initiation of therapy and rates of relapse after 28 days. Hypothesis: The administration of beta lactams in continuous infusion allows a clinical or microbiological cure greater than the intermittent administration.
Timeline
- Start
- 2006-09
- Primary completion
- 2007-12
- Completion
- 2007-12