Beta-Cell Function After Near-Normalisation of Blood Glucose

Summary

The incretin effect is attenuated in patients with type 2 diabetes mellitus partly due to impaired potentiation of beta-cell responsiveness to glucose by glucose dependent insulinotropic polypeptide and glucagon-like peptide-1 respectively. The aim of the present study was to investigate whether 4 weeks of near-normalization of blood glucose could improve the insulin responses to GIP and GLP-1 in patients with type 2 diabetes.

Timeline

Start

2006-10

Primary completion

2007-02

Completion

2007-05

Outcome

Met primary endpoint

paper The late phase C-peptide response (10-120 min) increased during GIP infusion from 33.0 +/- 8.5 to 103.9 +/- 24.2 (nmol/l) x (110 min)(-1) (p < 0.05) PMID 19037628 ↗

paper during GLP-1 infusion from 48.7 +/- 11.8 to 126.6 +/- 32.5 (nmol/l) x (110 min)(-1) (p < 0.05) PMID 19037628 ↗

Publications

• Hojberg PV, Vilsboll T, Rabol R, Knop FK, Bache M, Krarup T, Holst JJ, Madsbad S. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia. 2009 Feb;52(2):199-207. doi: 10.1007/s00125-008-1195-5. Epub 2008 Nov 27.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Glucagon-Like Peptide 1	Peptide	0.5 unknown	—
Subject	Glucose-dependent Insulinotropic Polypeptide	Peptide	1.5 unknown	—

Indications