Safety and PK of Nikkomycin Z for Coccidioides Pneumonia Treatment

Summary

The purpose of this study is to determine if nikkomycin Z is safe when administered at different dose levels for 14 days. The study will also determine blood levels and urinary excretion of nikkomycin Z in relation to dose administered. Patients with mild forms of Valley Fever pneumonia will be eligible to participate and will be allocated to receive treatment with nikkomycin Z (various doses) or a placebo. A secondary goal of this study is to evaluate the effectiveness and dose response of nikkomycin Z in an exploratory analysis.

Timeline

Start

2007-09

Primary completion

2009-09

Completion

2009-09

Outcome

Outcome not reported

Stopped (Enrollment): “Recruitment challenges and lack of funding caused an early end to this study”

Drugs

Indications