Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention

Phase 4 Completed 52 enrolled University of Cincinnati Mayfield Clinic & Spine Institute · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

To show that the use of intravenous levetiracetam(LEV;Keppra)for seizure prevention in patients in the Neuroscience Intensive Care Unit will result in fewer side effects compared to the current standard of care anticonvulsant and will be at least as effective as the current standard of care in preventing clinical and sub-clinical seizure activity.

Timeline

Start: 2007-08
Primary completion: 2009-09
Completion: 2009-09

Publications

Steinbaugh LA, Lindsell CJ, Shutter LA, Szaflarski JP. Initial EEG predicts outcomes in a trial of levetiracetam vs. fosphenytoin for seizure prevention. Epilepsy Behav. 2012 Mar;23(3):280-4. doi: 10.1016/j.yebeh.2011.12.005. Epub 2012 Feb 16.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Levetiracetam	Other / unclassified	1000 mg	Intravenous
Comparator	Phenytoin	Unknown	5 mg/kg	Intravenous

Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention

Summary

Timeline

Publications

Drugs

Indications