Phase 1-2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat

Phase 1/2 Completed 85 enrolled Kythera Biopharmaceuticals

RandomizedParallel-groupDouble-blindTreatment

Summary

To evaluate the safety and potential efficacy of deoxycholic acid injection compared to placebo for the reduction of submental fat (fat below the chin).

Timeline

Start: 2007-08
Primary completion: 2008-10
Completion: 2008-10

Publications

Goodman GJ, Spelman LJ, Lowe N, Bowen B. Randomized, Placebo-Controlled Phase 1/2 Study to Determine the Appropriate ATX-101 Concentration for Reduction of Submental Fat. Dermatol Surg. 2021 Aug 1;47(8):1065-1070. doi: 10.1097/DSS.0000000000003092.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Deoxycholic Acid	Small molecule	1 unknown	Other
Subject	Deoxycholic Acid	Small molecule	2 unknown	Other
Subject	Deoxycholic Acid	Small molecule	4 unknown	Other

Indications

No indication recorded.