Candesartan Effect in Second Stage Arterial Hypertension

Summary

To compare the changes in mean sitting DBP from baseline after 4 weeks of therapy with either candesartan cilexetil/HCT combination therapy or candesartan cilexetil monotherapy regimen

Timeline

Start

2008-02

Primary completion

2009-03

Completion

2009-03

Outcome

Met primary endpoint

paper The candesartan-HCT combination was associated with a statistically significant lowering of BP compared with candesartan monotherapy. PMID 21831438 ↗

Publications

• Lee HY, Hong BK, Chung WJ, Lee BK, Lee SH, Jeon DW, Ahn YK, Kim D, Park CK, Kim SH, Jung HO, Kim BO, Choi D. Phase IV, 8-week, multicenter, randomized, active treatment-controlled, parallel group, efficacy, and tolerability study of high-dose candesartan cilexetil combined with hydrochlorothiazide in Korean adults with stage II hypertension. Clin Ther. 2011 Aug;33(8):1043-56. doi: 10.1016/j.clinthera.2011.07.002. Epub 2011 Aug 10.

Drugs

Indications