Ribavirin for Hemorrhagic Fever With Renal Syndrome

Summary

Hemorrhagic Fever with Renal Syndrome (HFRS) is caused by a virus acquired by contact with chronically infected rodent hosts. HFRS is present throughout Korea. Treatment consists mainly of supportive care with careful attention to control of blood pressure and fluid balance and/or dialysis. Early initiation of IND Intravenous Ribavirin has been shown to be an effective treatment for HFRS and may prevent the need for dialysis. It is important to initiate therapy based on a diagnosis consistent with HFRS and a history that makes exposure likely. This study will monitor the clinical events that occur with HFRS as well as the safety and efficacy of Ribavirin.

Timeline

Start

2008-02

Primary completion

2019-12

Completion

2019-12

Outcome

Outcome not reported

Stopped (Enrollment): “This was an expanded access treatment protocol that did not enroll any subjects due to no infections requiring treatment.”

Drugs

Indications