Bioenergetic Alterations After Exenatide Administration

Summary

The purpose of this study is to find out how exenatide causes weight loss. Specifically, the study is assessing how exenatide may change how people take in energy (energy intake), as well as how it may effect how people use energy (energy expenditure).

Timeline

Start

2008-01

Primary completion

2010-04

Completion

2010-04

Outcome

Met primary endpoint

registry MEAN Exenitide Treatment: -167 (Standard Deviation 173) kcal/d NCT00623545 ↗

registry analysis (superiority or other test); Exenitide Treatment; p = 0.001; Mean Difference (Net) 185; ANOVA NCT00623545 ↗

Publications

• Results Bradley DP, Kulstad R, Schoeller DA. Exenatide and weight loss. Nutrition. 2010 Mar;26(3):243-9. doi: 10.1016/j.nut.2009.07.008.
• Bradley DP, Kulstad R, Racine N, Shenker Y, Meredith M, Schoeller DA. Alterations in energy balance following exenatide administration. Appl Physiol Nutr Metab. 2012 Oct;37(5):893-9. doi: 10.1139/h2012-068. Epub 2012 Jun 26.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Exenatide	Peptide	10 ug	Subcutaneous

Indications

No indication recorded.