AED/Statin Interaction Study

Phase 1 Completed 119 enrolled GlaxoSmithKline

Non-randomizedParallel-groupOpen-labelTreatment

Summary

This study will evaluate the amount of the cholesterol-lowering drug atorvastatin available in the bloodstream, when taken together with the anti-seizure drugs lamotrigine or phenytoin.

Timeline

Start: 2008-02-04
Primary completion: 2008-09-12
Completion: 2008-09-12

Publications

Background Bullman J, Nicholls A, Van Landingham K, Fleck R, Vuong A, Miller J, Alexander S, Messenheimer J. Effects of lamotrigine and phenytoin on the pharmacokinetics of atorvastatin in healthy volunteers. Epilepsia. 2011 Jul;52(7):1351-8. doi: 10.1111/j.1528-1167.2011.03118.x. Epub 2011 Jun 2.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Atorvastatin	Small molecule	40 mg	—
Comparator	Lamotrigine	Small molecule	300 mg	—
Comparator	Phenytoin	Unknown	4 mg/kg	—

AED/Statin Interaction Study

Summary

Timeline

Publications

Drugs

Indications