Self-dispersing Liquids as Aerosol Drug Carriers
Summary
Inhaled medications are often used to treat lung diseases such as cystic fibrosis. We are performing this study to determine whether inhaled medications dissolved in surfactant-based solutions will distribute more evenly throughout the lungs when compared to standard saline-based solutions. We think that inhaling medication that is in a surfactant-based liquid will result in more medication reaching partially blocked parts of the lung. This study will use a special nuclear medicine test called an aerosol deposition scan to compare how a drug spreads in the lung using a surfactant-based aerosol compared to a saline-based aerosol.
Timeline
- Start
- 2008-03
- Primary completion
- 2009-08
- Completion
- 2009-08
Outcome
Missed primary endpoint
registry analysis (superiority or other test); Subjects Inhaling Saline vs Subjects Inhaling Surfactant; p = 0.07; Wilcoxon (Mann-Whitney) NCT00628134 ↗
paper Our results lack statistical significance PMID 22393908 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Calfactant | Protein / enzyme biologic | — | Inhaled |