The Oral Contraceptive Pill for Premenstrual Worsening of Depression

Summary

To determine if augmentation with the oral-contraceptive pill containing drospirenone and ethinyl estradiol is more effective than placebo in the treatment of premenstrual breakthrough of depression.

Timeline

Start

2008-02

Primary completion

2011-05

Completion

2011-05

Outcome

Missed primary endpoint

registry Drospirenone and Ethinyl Estradiol vs Placebo; p = .59; Wilcoxon (Mann-Whitney) NCT00633360 ↗

Drugs

Indications