Safety and Efficacy of Gabapentin in Postherpetic Neuralgia

Summary

Gabapentin and pregabalin are treatments for some types of neuropathic pain, including postherpetic neuralgia (PHN). However, these treatments usually need to be taken 3 times a day for effective pain control. The purpose of this study is to determine whether a new gabapentin tablet, which only needs to be taken once a day, is safe and effective for the treatment of postherpetic neuralgia.

Timeline

Start

2008-03

Primary completion

2009-08

Completion

2009-09

Outcome

Met primary endpoint

registry analysis (superiority or other test); G-ER vs Placebo; p = 0.0125; Least squares mean difference -0.49 (95% CI -0.88 to -0.11); ANCOVA NCT00636636 ↗

Publications

• Mehta N, Bucior I, Bujanover S, Shah R, Gulati A. Relationship between pain relief, reduction in pain-associated sleep interference, and overall impression of improvement in patients with postherpetic neuralgia treated with extended-release gabapentin. Health Qual Life Outcomes. 2016 Apr 1;14:54. doi: 10.1186/s12955-016-0456-0.

Drugs

Indications