Dose-Dependent Effect of Thiazide in Dent's Disease Hypercalciuria

Phase 2/3 Terminated 10 enrolled Assistance Publique - Hôpitaux de Paris

Non-randomizedSingle-groupOpen-labelTreatment

Summary

Intrarenal calcifications (nephrocalcinosis) is present in Dent's disease and likely contribute to progression toward renal failure. In order to prevent this complication it is usually proposed to treat affected patients during childhood with high doses of thiazides.

Timeline

Start: 2003-07
Primary completion: 2005-12
Completion: 2005-12

Publications

Blanchard A, Vargas-Poussou R, Peyrard S, Mogenet A, Baudouin V, Boudailliez B, Charbit M, Deschesnes G, Ezzhair N, Loirat C, Macher MA, Niaudet P, Azizi M. Effect of hydrochlorothiazide on urinary calcium excretion in dent disease: an uncontrolled trial. Am J Kidney Dis. 2008 Dec;52(6):1084-95. doi: 10.1053/j.ajkd.2008.08.021. Epub 2008 Oct 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Hydrochlorothiazide	Unknown	6.25 mg	—
Subject	Hydrochlorothiazide	Unknown	12.5 mg	—
Subject	Hydrochlorothiazide	Unknown	25 mg	—

Dose-Dependent Effect of Thiazide in Dent's Disease Hypercalciuria

Summary

Timeline

Publications

Drugs

Indications