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drugset / Trial / NCT00639873

Artemisinin Resistance in Bangladesh

NCT00639873 ↗

Completed 126 enrolled Medical University of Vienna International Centre for Diarrhoeal Disease Research, Bangladesh · collab World Health Organization · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

A randomized, controlled clinical trial conducted in Southeastern Bangladesh using artesunate monotherapy to determine the baseline sensitivity of P. falciparum to artemisinins.

Timeline

Start: 2008-06
Primary completion: 2009-11
Completion: 2009-11

Publications

Starzengruber P, Swoboda P, Fuehrer HP, Khan WA, Hofecker V, Siedl A, Fally M, Graf O, Teja-Isavadharm P, Haque R, Ringwald P, Noedl H. Current status of artemisinin-resistant falciparum malaria in South Asia: a randomized controlled artesunate monotherapy trial in Bangladesh. PLoS One. 2012;7(12):e52236. doi: 10.1371/journal.pone.0052236. Epub 2012 Dec 18.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Artesunate	Small molecule	2 mg/kg	Oral
Subject	Artesunate	Small molecule	4 mg/kg	Oral
Comparator	Doxycycline	Small molecule	—	—
Comparator	Quinine	Small molecule	—	—

Indications