Abrupt Versus Tapered Interruption of Chronic Clopidogrel Therapy After DES Implantation

Summary

The hypothesis to be tested is that gradual clopidogrel therapy cessation is associated with a superior clinical outcome compared with abrupt cessation (superiority hypothesis).

Timeline

Start

2008-04

Primary completion

2012-08

Completion

2012-08

Outcome

Outcome not reported

Stopped (Enrollment): “Due to slow enrollment the study was stopped prematurely.”

Publications

• Results Fiedler KA, Mehilli J, Kufner S, Schlichting A, Ibrahim T, Sibbing D, Ott I, Schunkert H, Laugwitz KL, Kastrati A, Schulz S. Randomised, double-blind trial on the value of tapered discontinuation of clopidogrel maintenance therapy after drug-eluting stent implantation. Intracoronary Stenting and Antithrombotic Regimen: CAUTION in Discontinuing Clopidogrel Therapy--ISAR-CAUTION. Thromb Haemost. 2014 Jun;111(6):1041-9. doi: 10.1160/TH13-11-0900. Epub 2014 Mar 13.

Drugs

Indications