Anti-inflammatory Therapy With Anakinra in Newly Diagnosed Type 1 Diabetes

Summary

The purpose of this study is to determine whether control of inflammatory pathways mediated by IL-1 beta using the IL-1 receptor antagonist anakinra will yield measurable decreases in expression of genes that are otherwise overexpressed as a consequence of IL-1 beta effects in children with newly diagnosed type 1 diabetes. Ultimately, we believe that control of IL-1 beta pathways will be associated with preserved insulin secretory capacity.

Timeline

Start

2008-03

Primary completion

2009-09

Completion

2009-09

Publications

• Results Sumpter KM, Adhikari S, Grishman EK, White PC. Preliminary studies related to anti-interleukin-1beta therapy in children with newly diagnosed type 1 diabetes. Pediatr Diabetes. 2011 Nov;12(7):656-67. doi: 10.1111/j.1399-5448.2011.00761.x. Epub 2011 Apr 24.

Drugs

Indications