Microbial Invasion During Parenteral Nutrition in Surgical Infants Receiving Glutamine

Phase 4 Completed 60 enrolled Institute of Child Health

RandomizedSingle-groupTriple-blindOther

Summary

We hypothesise that the addition of glutamine supplementation to both parenteral nutrition and enteral feeds in surgical newborn infants leads to a reduction in bacterial invasion.

Timeline

Start: 2009-07
Primary completion: 2011-12
Completion: 2012-05

Publications

Results Bishay M, Simchowitz V, Harris K, Macdonald S, De Coppi P, Klein N, Eaton S, Pierro A; MIGS Trial Group. The Effect of Glutamine Supplementation on Microbial Invasion in Surgical Infants Requiring Parenteral Nutrition: Results of a Randomized Controlled Trial. JPEN J Parenter Enteral Nutr. 2020 Jan;44(1):80-91. doi: 10.1002/jpen.1700. Epub 2019 Sep 9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Dipeptiven	Peptide	0.6 g/kg	—

Indications

No indication recorded.