Topical Oestrogens and Antimuscarinics In The Treatment Of Detrusor Overactivity

Phase 2/3 Completed University of Insubria

Summary

Despite the great number of reports about the efficacy of oestrogens or antimuscarinics on OAB symptoms, so far no author has tried to investigate whether the concomitant administration of these two drugs, acting on two different pathophysiological mechanisms, could have a synergic effect reducing the rate of non-responders to treatment.

Timeline

Start: 2004-01
Primary completion: —
Completion: 2007-12

Outcome

Missed primary endpoint

paper There was no significant difference between the two groups in terms of efficacy of therapy: 80.6% in group 1 versus 82% in group 2 (p=0.86). PMID 18584946 ↗

Publications

Serati M, Salvatore S, Uccella S, Cardozo L, Bolis P. Is there a synergistic effect of topical oestrogens when administered with antimuscarinics in the treatment of symptomatic detrusor overactivity? Eur Urol. 2009 Mar;55(3):713-9. doi: 10.1016/j.eururo.2008.06.051. Epub 2008 Jun 20.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Tolterodine	Unknown	4 mg	—
Subject	oestriol	Unknown	—	Topical