drugset / Trial / NCT00648895
A Study of the Effect of Nebivolol to Evaluate Its Vasodilatory Effects in Hypertensive Patients
RandomizedParallel-groupDouble-blindTreatment
Summary
The study is designed to compare the effects of nebivolol (10, 20, 40mg/day) with another beta blocker, extended-release metoprolol, at a range of doses. Its purpose is to study the mechanism of action of nebivolol on forearm blood flow, nitric oxide availability and other biomarkers.
Timeline
- Start
- 2007-11
- Primary completion
- 2009-07
- Completion
- —
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Metoprolol ER (TM) | Unknown | 100 mg | Oral |
| Comparator | Metoprolol ER (TM) | Unknown | 200 mg | Oral |
| Comparator | Metoprolol ER (TM) | Unknown | 400 mg | Oral |
| Comparator | Nebivolol | Other / unclassified | 10 mg | Oral |
| Comparator | Nebivolol | Other / unclassified | 20 mg | Oral |
| Comparator | Nebivolol | Other / unclassified | 40 mg | Oral |