Evaluation of [123I] MNI-330 and SPECT as a Marker of Beta-amyloid Protein Deposition

Summary

The main objectives of this proposal are as follows: To assess the dynamic uptake and washout of 123-I MNI-330, a potential imaging biomarker for β-amyloid burden in brain, using single photon emission computed tomography (SPECT) in similarly aged Alzheimer's (AD) subjects and healthy controls To perform blood metabolite characterization of 123-I MNI-330 in healthy and AD subjects to determine the metabolic fate and nature of metabolites in assessment of 123-I MNI-330 as a single photon computed tomography (SPECT) brain imaging agent Evaluate the test/retest reproducibility of 123-I MNI-330 and SPECT in AD subjects and healthy controls

Timeline

Start

2008-03

Primary completion

2008-09-30

Completion

2008-09-30

Outcome

Outcome not reported

Stopped: “Data did not evidence \[123I\]MNI-330 as a useful tool in the detection of AD.”

Drugs

Indications