drugset / Trial / NCT00659178

Combination Study Of SB-485232 (Interleukin 18) And Doxil For Advanced Stage Epithelial Ovarian Cancer

NCT00659178

Phase 1 Completed 15 enrolled GlaxoSmithKline
Non-randomizedSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to identify a dose of SB-485232 which is safe, tolerable and biologically active when used in combination with pegylated liposomal doxorubicin (Doxil) in patients with epithelial ovarian cancer. This study will use a standard treatment regimen of pegylated liposomal doxorubicin (Doxil) in combination with rising doses of SB-485232. The dose selected from this study will be used in a future studies to evaluate the efficacy of this combination.

Timeline

Start
2008-06-18
Primary completion
2011-02-18
Completion
2011-02-18

Drugs

EvaluationDrugModalityDoseRoute
Subject IBOCTADEKIN Protein / enzyme biologic
Background Doxorubicin Other / unclassified