Chemotherapy and Radiation Following Pancreatic Surgery

Phase 2 Completed 53 enrolled Washington University School of Medicine

NaSingle-groupOpen-labelTreatment

Summary

To describe the overall survival and disease-free survival in pancreatic cancer patients treated with adjuvant chemoradiation with cisplatin, continuous infusion 5FU and interferon alpha followed by gemcitabine. To describe the toxicities associated with adjuvant chemoradiation with cisplatin. 5FU and interferon alfa followed by gemcitabine in patients with pancreatic cancers.

Timeline

Start: 2002-05
Primary completion: 2006-11
Completion: 2009-02

Publications

Linehan DC, Tan MC, Strasberg SM, Drebin JA, Hawkins WG, Picus J, Myerson RJ, Malyapa RS, Hull M, Trinkaus K, Tan BR Jr. Adjuvant interferon-based chemoradiation followed by gemcitabine for resected pancreatic adenocarcinoma: a single-institution phase II study. Ann Surg. 2008 Aug;248(2):145-51. doi: 10.1097/SLA.0b013e318181e4e9.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cisplatin	Other / unclassified	25 mg/m2	Intravenous
Subject	Gemcitabine	Small molecule	1000 mg/m2	Intravenous
Subject	fluorouracil	Small molecule	175 mg/m2	—
Subject	interferon alfa-2b	Protein / enzyme biologic	3e+06 iu	Subcutaneous

Chemotherapy and Radiation Following Pancreatic Surgery

Summary

Timeline

Publications

Drugs

Indications