High-dose Ribavirin in Treatment of Chronic Hepatitis C Genotype 1 or 4

Summary

Optimal ribavirin dosages are essential in achieving SVR (sustained virological response). Several studies have shown higher SVR rates in patients receiving higher doses of ribavirin. Therefore we propose a randomized controlled open label multicenter trial to investigate wether high (25-29mg/kg) dose ribavirin can improve outcome in patients in infected with hepatitis C virus genotype 1 or 4 compared to standard dose (12-15mg/kg).

Timeline

Start

2008-04

Primary completion

2013-06

Completion

2013-11

Drugs

Indications