Flu Vaccination in Congestive Heart Failure

Summary

We evaluated the preventive impact of vaccination on subsequent death events in 117 severe congestive heart patients requiring ventilator support without endotracheal intubations and aggressive medical therapy. They were randomly allocated in a single-blind manner as a unique intramuscular influenza vaccination or as controls. The first primary outcome evaluated at 6 months follow-up - cardiovascular death - occurred in 3% of the patients in the vaccine group Vs 17% in controls (p=0.022). The composite end point occurred in 33% of the patients in the vaccine group Vs 74% in control group, p = \<0.001.

Timeline

Start

2007-05

Primary completion

2008-03

Completion

2008-03

Drugs

Indications