Uptake of the Antifungal Miconazole and Effect on Estrogen Metabolizing Enzymes in Humans

Completed 20 enrolled University of Southern Denmark Odense University Hospital · collab

NaSingle-groupOpen-labelBasic science

Summary

The purpose of this study, is to study the uptake of the pharmaceutical antifungal miconazole when used as a vaginal suppository in young women. The investigators want to know if the uptake is big enough to cause a biological effect (effect on CYP1A2 and CYP3A4 activity).

Timeline

Start: 2008-04
Primary completion: 2008-08
Completion: 2008-08

Publications

Kjaerstad MB, Nielsen F, Nohr-Jensen L, Zwisler S, Brosen K, Andersen HR. Systemic uptake of miconazole during vaginal suppository use and effect on CYP1A2 and CYP3A4 associated enzyme activities in women. Eur J Clin Pharmacol. 2010 Dec;66(12):1189-97. doi: 10.1007/s00228-010-0906-2. Epub 2010 Oct 6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Miconazole	Small molecule	1200 mg	Other

Indications

No indication recorded.