Guanfacine Immediate-release Electrocardiogram Results (QTc) Study

Phase 1 Completed 83 enrolled Shire

RandomizedCrossoverQuadruple-blindBasic science

Summary

To assess the effect of immediate-release guanfacine hydrochloride, administered at therapeutic and supratherapeutic doses, on QT/QTc in healthy normal males and females

Timeline

Start: 2008-04-18
Primary completion: 2008-08-07
Completion: 2008-08-07

Publications

Martin P, Satin L, Kahn RS, Robinson A, Corcoran M, Purkayastha J, Youcha S, Ermer JC. A thorough QT study of guanfacine. Int J Clin Pharmacol Ther. 2015 Apr;53(4):301-16. doi: 10.5414/CP202065.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Guanfacine	Small molecule	4 mg	—
Subject	Guanfacine	Small molecule	8 mg	—
Comparator	Moxifloxacin	Small molecule	400 mg	—

Indications

No indication recorded.