CARE Network Maintenance Versus Intermittent Inhaled Steroids in Wheezing Toddlers (MIST)

Summary

Asthma affects about 4 million children in the United States and is a leading cause of hospitalizations and school absenteeism. Continuous wheezing in very young children may develop into asthma. Low doses of inhaled corticosteroids (ICS) are commonly prescribed to treat children with particularly bad wheezing episodes. This study will compare the safety and effectiveness of low doses of ICS taken daily versus higher doses of ICS taken only during respiratory tract illnesses for toddlers with continuous wheezing or coughing illnesses.

Timeline

Start

2008-08

Primary completion

2010-07

Completion

2010-07

Outcome

Missed primary endpoint

paper The daily regimen of budesonide did not differ significantly from the intermittent regimen with respect to the frequency of exacerbations, PMID 22111718 ↗

paper relative rate in the intermittent-regimen group, 0.99; 95% CI, 0.71 to 1.35; P=0.60 PMID 22111718 ↗

Publications

• Results Zeiger RS, Mauger D, Bacharier LB, Guilbert TW, Martinez FD, Lemanske RF Jr, Strunk RC, Covar R, Szefler SJ, Boehmer S, Jackson DJ, Sorkness CA, Gern JE, Kelly HW, Friedman NJ, Mellon MH, Schatz M, Morgan WJ, Chinchilli VM, Raissy HH, Bade E, Malka-Rais J, Beigelman A, Taussig LM; CARE Network of the National Heart, Lung, and Blood Institute. Daily or intermittent budesonide in preschool children with recurrent wheezing. N Engl J Med. 2011 Nov 24;365(21):1990-2001. doi: 10.1056/NEJMoa1104647.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Budesonide	Small molecule	0.5 mg	Inhaled
Subject	Budesonide	Small molecule	1 mg	Inhaled

Indications