The Effect of Autologous Autovaccine in Patients With Allergy on House-dust-mite

Summary

House dust mite allergy is a common problem, resulting in asthma, chronic swelling of the eyes, and running nose. The investigators test a possibility to immunize subjects sensitized against house dust mite with extracts from their own gut bacteria "auto-vaccination".

Timeline

Start

2006-07

Primary completion

2008-08

Completion

2010-12

Publications

• Background Halasa J. [Justification of treatment with autovaccine]. Med Dosw Mikrobiol. 1994;46(1-2 Suppl):5-9. No abstract available. Polish.
• Schulze J, Voss S, Zissler U, Rose MA, Zielen S, Schubert R. Airway responses and inflammation in subjects with asthma after four days of repeated high-single-dose allergen challenge. Respir Res. 2012 Sep 19;13(1):78. doi: 10.1186/1465-9921-13-78.
• Rose MA, Weigand B, Schubert R, Schulze J, Zielen S. Safety, tolerability, and impact on allergic inflammation of autologous E.coli autovaccine in the treatment of house dust mite asthma--a prospective open clinical trial. BMC Complement Altern Med. 2011 Jun 3;11:45. doi: 10.1186/1472-6882-11-45.

Drugs

Indications