drugset / Trial / NCT00677924

Zalutumumab With or Without Irinotecan Chemotherapy in Cetuximab-Refractory Colorectal Cancer

NCT00677924 ↗

Phase 1/2 Terminated 9 enrolled Genmab
RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this trial is to determine the safety and efficacy of Zalutumumab alone or in combination with Irinotecan for the treatment of patients with Colorectal Cancer

Timeline

Start
2008-04
Primary completion
2009-04
Completion
2009-04

Outcome

Outcome not reported

Stopped (Business): “Due to changes in portfolio review”

Publications

  • Results Mano M, Hendlisz A, Machiels JP, Ehrnrooth E, Aladdin H, Van Laethem JL. Phase I trial of zalutumumab and irinotecan in metastatic colorectal cancer patients who have failed irinotecan and cetuximab based therapy. J Clin Oncol 27 2009 (suppl;abstr e15028)

Drugs

EvaluationDrugModalityDoseRoute
Subject Zalutumumab Monoclonal antibody 8 mg/kg —
Subject Zalutumumab Monoclonal antibody 16 mg/kg —

Indications