Topical IL-1-Ra for Treatment of Posterior Blepharitis

Phase 1/2 Completed 75 enrolled Reza Dana, MD

RandomizedParallel-groupDouble-blindTreatment

Summary

The purpose of this study is to determine the effectiveness and safety of Topical Interleukin-1-Receptor Antagonist in treatment of signs and symptoms of posterior blepharitis.

Timeline

Start: 2008-01
Primary completion: 2010-05
Completion: 2010-10

Publications

Amparo F, Dastjerdi MH, Okanobo A, Ferrari G, Smaga L, Hamrah P, Jurkunas U, Schaumberg DA, Dana R. Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial. JAMA Ophthalmol. 2013 Jun;131(6):715-723. doi: 10.1001/jamaophthalmol.2013.195.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Anakinra	Protein / enzyme biologic	2.5 %	Topical
Comparator	Anakinra	Protein / enzyme biologic	5 %	Topical

Topical IL-1-Ra for Treatment of Posterior Blepharitis

Summary

Timeline

Publications

Drugs

Indications