drugset / Trial / NCT00687102
Cognition in the Study of Tamoxifen and Raloxifene
RandomizedParallel-groupTriple-blindPrevention
Summary
The purpose of this study is to assess the effects of tamoxifen and raloxifene on cognitive aging in selected cognitively-healthy women.
Timeline
- Start
- 2001-10
- Primary completion
- 2008-03
- Completion
- 2008-03
Publications
- Background Maki PM, Zonderman AB, Resnick SM. Enhanced verbal memory in nondemented elderly women receiving hormone-replacement therapy. Am J Psychiatry. 2001 Feb;158(2):227-33. doi: 10.1176/appi.ajp.158.2.227.
- Background Resnick SM, Metter EJ, Zonderman AB. Estrogen replacement therapy and longitudinal decline in visual memory. A possible protective effect? Neurology. 1997 Dec;49(6):1491-7. doi: 10.1212/wnl.49.6.1491.
- Background Resnick SM, Maki PM, Golski S, Kraut MA, Zonderman AB. Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance. Horm Behav. 1998 Oct;34(2):171-82. doi: 10.1006/hbeh.1998.1476.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Raloxifene | Other / unclassified | — | Oral |
| Subject | Tamoxifen | Small molecule | — | Oral |
Indications
No indication recorded.