Impact of Timing on the Efficacy of Zegerid 40 mg in Healing Reflux Esophagitis: A Pilot Study

Summary

The purpose of this study was to determine the effect of morning versus bedtime administration of omeprazole/sodium bicarbonate (Zegerid) on endoscopic healing for patients with moderate or severe reflux esophagitis. Our hypothesis was that bedtime administration of Zegerid would be superior in healing esophagitis compared to morning administration prior to a meal.

Timeline

Start

2008-01

Primary completion

2010-12

Completion

2010-12

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Omeprazole/Sodium Bicarbonate AM Dose vs Omeprazole/Sodium Bicarbonate PM Dose; p = 1.0; Fisher Exact NCT00693225 ↗

Drugs

Indications