The Effect of Docetaxel or Gemcitabine-based Chemotherapy in East Asian and Caucasian Patients

Phase 2 Completed 300 enrolled National University Hospital, Singapore

Non-randomizedParallel-groupOpen-labelTreatment

Summary

The aims of this study are: 1. to compare the toxicity profile and efficacy of gemcitabine/carboplatin or docetaxel in East Asian and Caucasian patients. 2. to determine the genotype distribution of genes involved in docetaxel and gemcitabine pathways in East Asian and Caucasian patients. 3. to evaluate the association between genotypes and 1. treatment toxicity 2. treatment efficacy 3. pharmacokinetics.

Timeline

Start: 2006-10
Primary completion: 2012-09
Completion: 2012-09

Publications

Limviphuvadh V, Tan CS, Konishi F, Jenjaroenpun P, Xiang JS, Kremenska Y, Mu YS, Syn N, Lee SC, Soo RA, Eisenhaber F, Maurer-Stroh S, Yong WP. Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy. BMC Cancer. 2018 May 11;18(1):555. doi: 10.1186/s12885-018-4471-x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Carboplatin	Small molecule	—	Intravenous
Subject	Docetaxel	Small molecule	75 mg/m2	Intravenous
Subject	Gemcitabine	Small molecule	1000 mg/m2	Intravenous

The Effect of Docetaxel or Gemcitabine-based Chemotherapy in East Asian and Caucasian Patients

Summary

Timeline

Publications

Drugs

Indications