A Study of MK0431 in Patients WIth Hepatic Insufficiency (0431-017)(COMPLETED)

Summary

A study to compare the plasma concentrations of MK0431 at different times in patients with hepatic insufficiency vs healthy control subjects.

Timeline

Start

2004-04

Primary completion

2004-05

Completion

2004-05

Outcome

Missed primary endpoint

paper The mean AUC(0-infinity) and Cmax for sitagliptin were numerically, but not significantly (p>0.050), higher PMID 19221403 ↗

Publications

• Results Migoya EM, Stevens CH, Bergman AJ, Luo WL, Lasseter KC, Dilzer SC, Davies MJ, Wagner JA, Herman GA. Effect of moderate hepatic insufficiency on the pharmacokinetics of sitagliptin. Can J Clin Pharmacol. 2009 Winter;16(1):e165-70. Epub 2009 Feb 16.

Drugs

Indications