Efficacy of Thrice Weekly Directly Observed Treatment, Short-course (DOTS) in HIV-associated Tuberculosis

Summary

Tuberculosis (TB) is the most common opportunistic infection among HIV infected persons living in developing countries. Directly observed treatment, short-course (DOTS) is the internationally recommended strategy for the treatment of TB. However, the efficacy of DOTS for the treatment of HIV-associated TB is not well studied. This study aims to compare the efficacy of thrice weekly DOTS in HIV-infected versus HIV-negative patients with TB.

Timeline

Start

2006-04

Primary completion

2010-09

Completion

2011-04

Publications

• Vashishtha R, Mohan K, Singh B, Devarapu SK, Sreenivas V, Ranjan S, Gupta D, Sinha S, Sharma SK. Efficacy and safety of thrice weekly DOTS in tuberculosis patients with and without HIV co-infection: an observational study. BMC Infect Dis. 2013 Oct 7;13:468. doi: 10.1186/1471-2334-13-468.

Drugs

Indications