A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese Subjects

Phase 2 Completed 46 enrolled Orexigen Therapeutics, Inc

RandomizedParallel-groupTriple-blindBasic science

Summary

The purpose of this study was to assess the effect of naltrexone SR/bupropion SR (NB) on brain function in response to food cues using functional magnetic resonance imaging in overweight or obese subjects.

Timeline

Start: 2008-09
Primary completion: 2010-06
Completion: 2010-06

Publications

Background Wang GJ, Tomasi D, Volkow ND, Wang R, Telang F, Caparelli EC, Dunayevich E. Effect of combined naltrexone and bupropion therapy on the brain's reactivity to food cues. Int J Obes (Lond). 2014 May;38(5):682-8. doi: 10.1038/ijo.2013.145. Epub 2013 Aug 8.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bupropion	Small molecule	360 mg	—
Subject	Naltrexone	Small molecule	32 mg	—

A Study Using Functional Magnetic Resonance Imaging (fMRI) to Assess the Effects of Naltrexone SR/ Bupropion SR Therapy in Overweight or Obese Subjects

Summary

Timeline

Publications

Drugs

Indications