Comparison of the Effect of Exenatide Versus Sitagliptin on 24-hour Average Glucose in Patients With Type 2 Diabetes on Metformin or a Thiazolidinedione

Summary

This study is designed to compare the short-term effects and mechanisms of action of exenatide with those of sitagliptin when either is added to an oral agent(metformin or a thiazolidinedione \[TZD\]) in adult patients with type 2 diabetes mellitus(T2DM) with inadequate glycemic control.

Timeline

Start

2008-08

Primary completion

2009-10

Completion

2009-10

Outcome

Met primary endpoint

registry LEAST_SQUARES_MEAN Exenatide: -41.65 (Standard Error 2.55) mg/dL LEAST_SQUARES_MEAN Sitagliptin: -29.56 (Standard Error 2.58) mg/dL analysis (superiority or other test); Exenatide vs Sitagliptin; p <.001 NCT00729326 ↗

Drugs

Indications