drugset / Trial / NCT00731055
Effects of Varenicline on Cigarette Self Administration
Phase 2
Completed
16 enrolled
New York State Psychiatric Institute
National Institute on Drug Abuse (NIDA) · collab
RandomizedCrossoverDouble-blindTreatment
Summary
The investigators hypothesize that varenicline will dose dependently attenuate the subjective effects of cigarettes after a period of abstinence. Also, treatment with varenicline will dose dependently weaken the severity of nicotine withdrawal symptoms. Thirdly, we hypothesize that treatment with varenicline will dose dependently decrease cigarette self-administration in the model proposed.
Timeline
- Start
- 2008-02
- Primary completion
- 2009-05
- Completion
- 2009-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Varenicline | Small molecule | 0 mg | — |
| Subject | Varenicline | Small molecule | 0.5 mg | — |
| Subject | Varenicline | Small molecule | 1 mg | — |
| Subject | Varenicline | Small molecule | 2 mg | — |