Caffeine and Cocaine

Phase 1/2 Completed 23 enrolled Virginia Commonwealth University National Institute on Drug Abuse (NIDA) · collab The University of Texas Health Science Center, Houston · collab

Non-randomizedCrossoverQuadruple-blindBasic science

Summary

This study is being done to find out if medicines that affect a neurotransmitter (chemical messenger) in the brain called adenosine improve behavioral problems that are related to drug abuse. Another purpose of the study is to find out how genes related to adenosine change how people respond to these medicines. More information about how these medicines change behaviors may be helpful to come up with new treatments for drug abuse.

Timeline

Start: 2008-04
Primary completion: 2011-07
Completion: 2011-10

Publications

Results Lane SD, Green CE, Schmitz JM, Rathnayaka N, Fang WB, Ferre S, Moeller FG. Comparison of Caffeine and d-amphetamine in Cocaine-Dependent Subjects: Differential Outcomes on Subjective and Cardiovascular Effects, Reward Learning, and Salivary Paraxanthine. J Addict Res Ther. 2014;5(2):176. doi: 10.4172/2155-6105.1000176.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Amphetamine	Unknown	20 mg	—
Subject	Caffeine	Small molecule	150 mg	Oral
Subject	Caffeine	Small molecule	300 mg	Oral

Caffeine and Cocaine

Summary

Timeline

Publications

Drugs

Indications