Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury

Summary

This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI). After several protocol modifications, the purpose of the study is to test the effectiveness of a sub-therapeutic dose of Venlafaxine HCl to reduce mild to moderate symptoms in persons with SCI.

Timeline

Start

2008-06

Primary completion

2012-06

Completion

2012-08

Outcome

Missed primary endpoint

registry analysis (superiority or other test); Venlafaxine vs Placebo; p = 0.445; Fisher Exact NCT00735670 ↗

Drugs

Indications