Using D-cycloserine to Enhance the Benefits of Cognitive Behavioral Therapy for Schizophrenia

NCT00742079 ↗

Phase 4 Completed 21 enrolled Massachusetts General Hospital National Institute of Mental Health (NIMH) · collab

RandomizedCrossoverQuadruple-blindTreatment

Summary

This study will examine whether pretreatment with D-cycloserine before cognitive behavioral therapy can reduce impairments still present in people with stable cases of schizophrenia as well as determine which traits make schizophrenics most likely to respond to D-cycloserine treatment.

Timeline

Start: 2006-09
Primary completion: 2010-07
Completion: 2010-12

Outcome

Missed primary endpoint

paper Contrary to prediction, there was no significant d-cycloserine treatment effect on delusional distress or severity as measured by the SAPS or PSYRATS. PMID 21723096 ↗

Publications

Results Gottlieb JD, Cather C, Shanahan M, Creedon T, Macklin EA, Goff DC. D-cycloserine facilitation of cognitive behavioral therapy for delusions in schizophrenia. Schizophr Res. 2011 Sep;131(1-3):69-74. doi: 10.1016/j.schres.2011.05.029. Epub 2011 Jun 30.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cycloserine	Small molecule	50 mg	—