drugset / Trial / NCT00743210
Oral L-Citrulline and ADMA in Pregnancy
Phase 1
Completed
41 enrolled
University of Pittsburgh
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · collab
RandomizedParallel-groupDouble-blindBasic science
Summary
The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to obese subjects will decrease the plasma ADMA/L-arginine ratio, lower maternal blood pressure, improve endothelial-dependent vascular function and peripheral vascular stiffness, and improve uterine artery Doppler resistance and flow.
Timeline
- Start
- 2010-01
- Primary completion
- 2013-06
- Completion
- 2013-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | L-citrulline | Other / unclassified | 3 g | Oral |