Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders

Phase 1 Completed 22 enrolled Duke University

Non-randomizedSingle-groupOpen-labelTreatment

Summary

The primary objective is to determine the feasibility of attaining acceptable rates of donor cell engraftment (\>25% donor chimerism at 180 days) following reduced intensity conditioning (RIC) regimens in pediatric patients \< 21 years receiving cord blood transplantation for non-malignant disorders.

Timeline

Start: 2008-10
Primary completion: 2012-12
Completion: 2014-04

Publications

Parikh SH, Mendizabal A, Benjamin CL, Komanduri KV, Antony J, Petrovic A, Hale G, Driscoll TA, Martin PL, Page KM, Flickinger K, Moffet J, Niedzwiecki D, Kurtzberg J, Szabolcs P. A novel reduced-intensity conditioning regimen for unrelated umbilical cord blood transplantation in children with nonmalignant diseases. Biol Blood Marrow Transplant. 2014 Mar;20(3):326-36. doi: 10.1016/j.bbmt.2013.11.021. Epub 2013 Dec 1.

Drugs

Evaluation	Drug	Modality	Dose	Route
Background	Alemtuzumab	Monoclonal antibody	—	—
Background	Fludarabine	Small molecule	—	—
Background	Hydroxyurea	Other / unclassified	—	—
Background	Melphalan	Small molecule	—	—
Background	Thiotepa	Other / unclassified	—	—

Reduced Intensity Conditioning for Umbilical Cord Blood Transplant in Pediatric Patients With Non-Malignant Disorders

Summary

Timeline

Publications

Drugs

Indications